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Phenotypes Associated with This Genotype
Genotype
MGI:7703099
Allelic
Composition
Mettm1Sst/Mettm1Sst
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Sst mutation (1 available); any Met mutation (81 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased FOS+ infragranular neurons in the medial prefrontal cortex of male and female mice at P90 compared with controls
• however, FOS+ cells are normal in number at P35 during fear memory expression

behavior/neurological
• at P90 in female mice
• however, female and male mice exhibit normal contextual fear memory formation and persistence at P23 as well as contextual remote fear memory at P35 and 50


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/20/2026
MGI 6.24
The Jackson Laboratory