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Phenotypes Associated with This Genotype
Genotype
MGI:7646987
Allelic
Composition		 Cd79atm1(cre)Reth/Cd79a+
Eif4a1tm1.1Bea/Eif4a1tm1.1Bea
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (29 available)
Eif4a1tm1.1Bea mutation (0 available); any Eif4a1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased pro-B cell number ( J:344730 )
• greater than 20-fold reduction in pro B or Hardy Fraction B cells in the bone marrow
• remaining pro B cells have only a minor reduction in EIF4A1 and a 10-fold increase in EIF4A2
decreased B cell number ( J:344730 )
• almost complete loss of splenic B cells

immune system
decreased pro-B cell number ( J:344730 )
• greater than 20-fold reduction in pro B or Hardy Fraction B cells in the bone marrow
• remaining pro B cells have only a minor reduction in EIF4A1 and a 10-fold increase in EIF4A2
decreased B cell number ( J:344730 )
• almost complete loss of splenic B cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory