Phenotypes for 2310065F04Rik Ino80 Pax7 MGI:7645255 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	2310065F04Rik^tm1.1Boet/2310065F04Rik^tm1.1Boet Ino80^tm1.1Jland/Ino80^tm1.1Jland Pax7^tm1(cre)Mrc/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2310065F04Rik^tm1.1Boet mutation (0 available); any 2310065F04Rik mutation (0 available)
Ino80^tm1.1Jland mutation (1 available); any Ino80 mutation (438 available)
Pax7^tm1(cre)Mrc mutation (2 available); any Pax7 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:306156 )

N	• the increased body weight seen in homozygous 2310065F04Rik^tm1.1Boet mice is normalized

muscle

muscle phenotype ( J:306156 )

• mice show complete abrogation of the increased number of Pax7+ muscle stem cells (satellite cells) and of the increased EdU-labeled quiescent muscle stem cells, the increased tibialis anterior muscle weight, and the muscle hypertrophy and increased myonuclei numbers in fibers that are seen in homozygous 2310065F04Rik^tm1.1Boet mice

• mice do not show the general myofiber hypertrophy that is seen in homozygous 2310065F04Rik^tm1.1Boet mice 4 weeks after cardiotoxin-induced muscle damage

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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