Ino80^tm1.1Jland
Targeted Allele Detail

Summary

• Symbol: Ino80^tm1.1Jland
• Name: INO80 complex subunit; targeted mutation 1.1, Joseph Landry
• MGI ID: MGI:5698242
• Synonyms: Ino80^fl, Ino80 Floxed
• Gene: Ino80 Location: Chr2:119203523-119308168 bp, - strand Genetic Position: Chr2, 59.97 cM, cytoband E5
• Alliance: Ino80^tm1.1Jland page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229516
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to have a loxP site upstream of exon 2, and an FRT-flanked neo cassette followed by a second loxP site just downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 2 through 4 floxed. (J:229516)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ino80 Mutation: 440 strains or lines available

References

• Original: J:229516 Qiu Z, et al., Ino80 is essential for proximal-distal axis asymmetry in part by regulating Bmp4 expression. BMC Biol. 2016;14(1):18
• All: 3 reference(s)