Phenotypes Associated with This Genotype

Genotype
MGI:7643361

• Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺; Il1r2^tm1.1Epi/Il1r2^tm1.1Epi
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T follicular helper cell number ( J:347877 )

• tamoxifen-treated mice challenged with sheep red blood cell (sRBC) immunization show an increase in T follicular cells

increased spleen germinal center size ( J:347877 )

• tamoxifen-treated mice challenged with sRBC immunization show expanded germinal center (increased GL7/B220+ B cells)

abnormal adaptive immunity ( J:347877 )

• mice treated with tamoxifen in adulthood and challenged with sRBC immunization show altered adaptive response after immunization, with more T follicular (Tfol) cells, expanded germinal centers (GCs; increased GL7/B220+ B cells) and higher titers of serum anti-sRBC IgG

increased IgG level ( J:347877 )

• tamoxifen-treated mice challenged with sRBC immunization show higher titers of serum anti-sRBC IgG

hematopoietic system

increased T follicular helper cell number ( J:347877 )

• tamoxifen-treated mice challenged with sheep red blood cell (sRBC) immunization show an increase in T follicular cells

increased spleen germinal center size ( J:347877 )

• tamoxifen-treated mice challenged with sRBC immunization show expanded germinal center (increased GL7/B220+ B cells)

increased IgG level ( J:347877 )

• tamoxifen-treated mice challenged with sRBC immunization show higher titers of serum anti-sRBC IgG