Phenotypes Associated with This Genotype

Genotype
MGI:7640223

• Allelic Composition: Eogt^tm1.2Okaj/Eogt^tm1.2Okaj; Notch1^tm1Con/Notch1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:254752 )

• retinal vascular defects are enhanced in P5 and P15 mice compared to either single mutant, with even greater vessel branching and number of filopodia at the vascular front

increased vascular permeability ( J:254752 )

• retinas show greater extravascular fibrinogen staining and extravasation of perfused sulfo-NHS-LC-biotin, indicating greater impaired vascular integrity than single Eogt homozygotes

vision/eye

abnormal retina vasculature morphology ( J:254752 )

• retinal vascular defects are enhanced in P5 and P15 mice compared to either single mutant, with even greater vessel branching and number of filopodia at the vascular front