Phenotypes Associated with This Genotype

Genotype
MGI:7624074

• Allelic Composition: Rinl^tm1.1Boun/Rinl^tm1.1Boun; Tg(TcraTcrb)425Cbn/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T follicular helper cell differentiation ( J:346452 )

• increased frequency of CD44+ effector T cells in germinal centers but not in lymph nodes, indicating a defect in differentiation but not homing of these cells

increased CD4-positive, alpha-beta T cell number ( J:346452 )

• increased frequency of CD44+ effector T cells in germinal centers but not in lymph nodes, indicating a defect in differentiation but not homing of these cells

increased T follicular helper cell number ( J:346452 )

• increase in the frequency of CXCR5+/ICOS+ T follicular helper cells

• significant increase in PD-1+ CXCR5+ T follicular helper cells 7 days after immunization

hematopoietic system

abnormal T follicular helper cell differentiation ( J:346452 )

• increased frequency of CD44+ effector T cells in germinal centers but not in lymph nodes, indicating a defect in differentiation but not homing of these cells

increased CD4-positive, alpha-beta T cell number ( J:346452 )

• increased frequency of CD44+ effector T cells in germinal centers but not in lymph nodes, indicating a defect in differentiation but not homing of these cells

increased T follicular helper cell number ( J:346452 )

• increase in the frequency of CXCR5+/ICOS+ T follicular helper cells

• significant increase in PD-1+ CXCR5+ T follicular helper cells 7 days after immunization