Rinl^tm1.1Boun
Targeted Allele Detail

Summary

• Symbol: Rinl^tm1.1Boun
• Name: Ras and Rab interactor-like; targeted mutation 1.1, Nicole Boucheron
• MGI ID: MGI:7623983
• Gene: Rinl Location: Chr7:28488394-28498388 bp, + strand Genetic Position: Chr7, 16.93 cM, cytoband A3
• Alliance: Rinl^tm1.1Boun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:346452
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A stop codon, IRES-lacZ-GFP cassette, and floxed neo cassette were inserted in the reading frame of exon 4. Cre mediated recombination removed the neo cassette. No reporter expression was detected. Immunoblot analysis confirmed the absence of protein expression in homozygous mice. (J:346452)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rinl Mutation: 31 strains or lines available

References

• Original: J:346452 Sandner L, et al., The guanine nucleotide exchange factor Rin-like controls Tfh cell differentiation via CD28 signaling. J Exp Med. 2023 Nov 6;220(11)
• All: 1 reference(s)