Phenotypes Associated with This Genotype

Genotype
MGI:7623993

• Allelic Composition: Rinl^tm1.1Boun/Rinl^tm1.1Boun
• Genetic Background: B6.Cg-Rinl^tm1.1Boun

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:346452 )

N • frequencies of double negative, double positive, and single positive T cells in the thymus are similar to controls

enlarged spleen ( J:346452 )

• increase in spleen weight and cell numbers in aged mice

increased B cell number ( J:346452 )

• increase in frequencies of B cells in mice at 8 and 12 weeks of age in the spleen

• increase in IgG1+ B cells at 8 and 21 days after LCMV infection

increased germinal center B cell number ( J:346452 )

• increase in germinal center B cells in spleens and lymph nodes in aged mice

• increased after immunization compared to similarly immunized wild-type controls

• increased at 8 and 21 days after LCMV infection

increased CD4-positive, alpha-beta T cell number ( J:346452 )

• increase in the frequencies of effector CD4+ T cells in the spleen

• however, numbers of CD8+ T cells and other T helper cell subsets are unchanged

increased T follicular helper cell number ( J:346452 )

• increase in spleens and lymph nodes in aged mice

• increase in relative and absolute numbers 7 days after immunization compared to similarly immunized wild-type controls

• following infection with LCMV increase in the number of virus-specific gp66 tetramer-positive CD4+ T cell

increased splenocyte number ( J:346452 )

• strong increase in total splenocyte number

• increase in splenocyte numbers at 8 days following lymphocytic choriomeningitis virus infection with significant expansion of CD4+ T helper cells compared to similarly infected wild-type mice

abnormal susceptibility to Riboviria infection ( J:346452 )

• increase in splenocyte numbers at 8 days following lymphocytic choriomeningitis virus (LCMV) infection with significant expansion of CD4+ T helper cells compared to similarly infected wild-type mice

growth/size/body

enlarged spleen ( J:346452 )

• increase in spleen weight and cell numbers in aged mice

hematopoietic system

enlarged spleen ( J:346452 )

• increase in spleen weight and cell numbers in aged mice

increased B cell number ( J:346452 )

• increase in frequencies of B cells in mice at 8 and 12 weeks of age in the spleen

• increase in IgG1+ B cells at 8 and 21 days after LCMV infection

increased germinal center B cell number ( J:346452 )

• increase in germinal center B cells in spleens and lymph nodes in aged mice

• increased after immunization compared to similarly immunized wild-type controls

• increased at 8 and 21 days after LCMV infection

increased CD4-positive, alpha-beta T cell number ( J:346452 )

• increase in the frequencies of effector CD4+ T cells in the spleen

• however, numbers of CD8+ T cells and other T helper cell subsets are unchanged

increased T follicular helper cell number ( J:346452 )

• increase in spleens and lymph nodes in aged mice

• increase in relative and absolute numbers 7 days after immunization compared to similarly immunized wild-type controls

• following infection with LCMV increase in the number of virus-specific gp66 tetramer-positive CD4+ T cell

increased splenocyte number ( J:346452 )

• strong increase in total splenocyte number

• increase in splenocyte numbers at 8 days following lymphocytic choriomeningitis virus infection with significant expansion of CD4+ T helper cells compared to similarly infected wild-type mice