Phenotypes for Speer6-ps1 Tor1a Tor1aip1 MGI:7611647 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tor1a^tm3.1Wtd/Tor1a^tm3.1Wtd Tor1aip1^tm1.1Wtd/Tor1aip1^tm1.1Wtd Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
Tor1aip1^tm1.1Wtd mutation (1 available); any Tor1aip1 mutation (41 available)
Tor1a^tm3.1Wtd mutation (1 available); any Tor1a mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

abnormal hepatocyte morphology ( J:345574 )

• decrease in the number of nuclei containing 2 or more lipid droplets compared to mutant mice wild-type for Tor1a, 7 +/- 3% compared to 64 +/- 5%

hepatic steatosis ( J:345574 )

• grossly white livers

abnormal liver physiology ( J:345574 )

• decreased triglyceride, apoB100, and apoB48 secretion rates

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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