Phenotypes Associated with This Genotype

Genotype
MGI:7608061

• Allelic Composition: Lamp5^em1Lmit/Lamp5^em1Lmit; Tg(Thy1-MAPT*P301S)58.2Npa/0
• Genetic Background: involves: C57BL/6 * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:345459 )

N • mice show similar survival as single Tg(Thy1-MAPT*P301S)58.2Npa hemizygotes or single Lamp5^em1Lmit homozygotes

behavior/neurological

impaired spatial learning ( J:345459 )

• mice show impaired learning in the Morris water maze compared to single Tg(Thy1-MAPT*P301S)58.2Npa hemizygotes

abnormal spatial reference memory ( J:345459 )

• mice show impaired memory in the Morris water maze compared to single Tg(Thy1-MAPT*P301S)58.2Npa hemizygotes

nervous system

abnormal brain wave pattern ( J:345459 )

• EEG recording shows increased numbers of spontaneous discharges and elevated high frequency spectral power while frequency of spectral power (theta) is reduced and theta/gamma cross frequency coupling, an EEG measure linked to memory, is compromised compared to single Tg(Thy1-MAPT*P301S)58.2Npa hemizyotes