Phenotypes Associated with This Genotype

Genotype
MGI:7608059

• Allelic Composition: Lamp5^em1Lmit/Lamp5⁺; Tg(Thy1-APP)3Somm/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:345459 )

• survival is reduced similarly to that seen in single Tg(Thy1-APP)3Somm hemizygotes until 150 days and thereafter shows a trend towards increased mortality

behavior/neurological

impaired spatial learning ( J:345459 )

• learning in the Morris water maze is impaired compared to single Tg(Thy1-APP)3Somm hemizygotes at 12 months of age

abnormal spatial reference memory ( J:345459 )

• memory formation in the Morris water maze is impaired compared to single Tg(Thy1-APP)3Somm hemizygotes at 12 months of age

homeostasis/metabolism

amyloid beta deposits ( J:345459 )

• amyloid beta formation and plaque load in aged mice is similar to single Tg(Thy1-APP)3Somm hemizygotes

nervous system

amyloid beta deposits ( J:345459 )

• amyloid beta formation and plaque load in aged mice is similar to single Tg(Thy1-APP)3Somm hemizygotes

abnormal brain wave pattern ( J:345459 )

• spectral power at gamma (30-100 Hz) frequency is increased more than in single Tg(Thy1-APP)3Somm hemizygotes, indicating neuronal network hypersynchronicity

• theta/gamma cross frequency coupling, an EEG measure linked to memory, is disrupted more than in single Tg(Thy1-APP)3Somm hemizygotes