Phenotypes Associated with This Genotype

Genotype
MGI:7608057

• Allelic Composition: Lamp5^em1Lmit/Lamp5⁺
• Genetic Background: C57BL/6-Lamp5^em1Lmit

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:345459 )

• mice exhibit an increase in severity and reduced latency of pentylenetetrazole-induced excitotoxic seizure than in wild-type mice

abnormal habituation to a new environment ( J:345459 )

• mice show delayed habituation in the open field task

• however, no hyperactivity is seen

nervous system

increased susceptibility to pharmacologically induced seizures ( J:345459 )

• mice exhibit an increase in severity and reduced latency of pentylenetetrazole-induced excitotoxic seizure than in wild-type mice

mortality/aging

mortality/aging ( J:345459 )

N • mice exhibit normal survival