Phenotypes Associated with This Genotype

Genotype
MGI:7608056

• Allelic Composition: Lamp5^em1Lmit/Lamp5^em1Lmit
• Genetic Background: C57BL/6-Lamp5^em1Lmit

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:345459 )

• mice exhibit an increase in severity and reduced latency of pentylenetetrazole-induced excitotoxic seizure than in heterozygotes or wild-type mice

abnormal habituation to a new environment ( J:345459 )

• mice show delayed habituation in the open field task

• however, no hyperactivity is seen

nervous system

increased susceptibility to pharmacologically induced seizures ( J:345459 )

• mice exhibit an increase in severity and reduced latency of pentylenetetrazole-induced excitotoxic seizure than in heterozygotes or wild-type mice

abnormal brain interneuron morphology ( J:345459 )

• when injected with an adeno-associated virus encoding a Lamp5 promoter-driven GFP reporter, mice show normal development of LAMP5+ interneurons at 1 months of age, however by 3-months of age, mice show a loss of LAMP5+ interneurons and dystrophic neurites in the cortex and dentate gyrus

neurite dystrophy ( J:345459 )

• when injected with an adeno-associated virus encoding a Lamp5 promoter-driven GFP reporter, mice show normal development of LAMP5+ interneurons at 1 months of age, however by 3-months of age, mice show dystrophic neurites in the cortex and dentate gyrus

abnormal brain wave pattern ( J:345459 )

• hippocampal EEG recordings show frequent spontaneous discharge events and increased high frequency power

• spectral power analysis shows increased high frequency power compared to controls

mortality/aging

mortality/aging ( J:345459 )

N • mice exhibit normal survival