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Phenotypes Associated with This Genotype
Genotype
MGI:7560661
Allelic
Composition		 Dvl2tm1.2Wds/Dvl2tm1.2Wds
Shroom3Gt(ROSA53)Sor/Shroom3Gt(ROSA53)Sor
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2tm1.2Wds mutation (0 available); any Dvl2 mutation (33 available)
Shroom3Gt(ROSA53)Sor mutation (1 available); any Shroom3 mutation (206 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:293794 )
• when Shroom3Gt(ROSA53)Sor/Shroom3+; Dvl2tm1.2Wds/Dvl2+ are crossed to Shroom3Gt(ROSA53)Sor/Shroom3+; Dvl2tm1.2Wds/Dvl2tm1.2Wds, no double knockout male mice are recovered at E14.5 (zero versus expected 4.75), indicating a sex bias due to Dvl2 loss

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory