Phenotypes Associated with This Genotype

Genotype
MGI:7549325

• Allelic Composition: Phrf1^em1Mscha/Phrf1^em1Mscha; Tg(Camk2a-cre)T29-1Stl/0
• Genetic Background: involves: BALB/c * C57BL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:294183 )

N • mice exhibit normal paired-pulse facilitation and long-term potentiation

abnormal Purkinje cell dendrite morphology ( J:294183 )

• reduced dendritic complexity, decreased dendritic branches, and reduced internodal segment length of CA1 pyramidal neurons

impaired synaptic plasticity ( J:294183 )

• after TGF-beta1 treatment

behavior/neurological

impaired spatial learning ( J:294183 )

• reduced spontaneous alternations in a Y-maze

abnormal spatial working memory ( J:294183 )

• in a Morris water maze

increased anxiety-related response ( J:294183 )

• in an open field, mice spend more time on the peripheral and less in the central areas compared with control mice

• in an elevated-plus maze, mice spend more time in the closed arm and less time in the open arm compared with control mice

• in a light/dark box, mice spend less time in the light area compared with control mice

increased thigmotaxis ( J:294183 )

• in an open field

abnormal response to novel object ( J:294183 )

• mice spend more time exploring a novel object than a familiar one compared with control mice