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Phenotypes Associated with This Genotype
Genotype
MGI:7491700
Allelic
Composition		 Lgr5tm1(cre/ERT2)Cle/Lgr5+
Stk26tm2.1Zzh/Stk26tm2.1Zzh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
Stk26tm2.1Zzh mutation (0 available); any Stk26 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal enterocyte proliferation ( J:322311 )
• reduced proliferation of intestinal stem cells after 5-fluoruracil (5-FU)-induced killing of proliferating intestinal cells

digestive/alimentary system
abnormal enterocyte proliferation ( J:322311 )
• reduced proliferation of intestinal stem cells after 5-fluoruracil (5-FU)-induced killing of proliferating intestinal cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory