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Phenotypes Associated with This Genotype
Genotype
MGI:7490266
Allelic
Composition		 Notch1tm1Con/Notch1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1tm1Con mutation (3 available); any Notch1 mutation (116 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:254752 )
• retinas show increased vessel branching at P15 and a higher number of filopodia at the vascular front

vision/eye
abnormal retina vasculature morphology ( J:254752 )
• retinas show increased vessel branching at P15 and a higher number of filopodia at the vascular front

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory