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Phenotypes Associated with This Genotype
Genotype
MGI:7489843
Allelic
Composition		 Smc3tm1.1Toshi/Smc3tm1.1Toshi
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 B6.Cg-H2az2Tg(Wnt1-cre)11Rth Smc3tm1.1Toshi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Smc3tm1.1Toshi mutation (0 available); any Smc3 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
small cranium ( J:242006 )
• at P0.5, mice exhibit a significantly smaller skull than control mice
cleft palate ( J:242006 )
• at E17.5, mice exhibit a cleft palate

skeleton
small cranium ( J:242006 )
• at P0.5, mice exhibit a significantly smaller skull than control mice

growth/size/body
cleft palate ( J:242006 )
• at E17.5, mice exhibit a cleft palate

digestive/alimentary system
cleft palate ( J:242006 )
• at E17.5, mice exhibit a cleft palate

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory