Phenotypes for Rr420 Tg(Sp7-tTA,tetO-EGFP/cre)1Amc Trp53 MGI:7486534 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Rr420^tm1.1Itok/Rr420^tm1.1Itok Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr420^tm1.1Itok mutation (0 available); any Rr420 mutation (0 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (7 available)
Trp53^tm1Brn mutation (21 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased tumor-free survival time ( J:319454 )

• survival time is increased compared to mutant mice wild-type for Rr420

neoplasm

decreased osteosarcoma incidence ( J:319454 )

• decreased incidence compared to mutant mice wild-type for Rr420

• decrease is similar to mutant osteosarcoma model mice homozygous for Runx3^tm1.1Itok

skeleton

decreased osteosarcoma incidence ( J:319454 )

• decreased incidence compared to mutant mice wild-type for Rr420

• decrease is similar to mutant osteosarcoma model mice homozygous for Runx3^tm1.1Itok

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24