Phenotypes Associated with This Genotype

Genotype
MGI:7486124

• Allelic Composition: Prmt1^{tm1c(EUCOMM)Wtsi}/Prmt1⁺; Rb1^tm3Tyj/Rb1^tm3Tyj; Trp53^tm1Brn/Trp53^tm1Brn; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:245660 )

• mice begin to die at ~100 days of age and all die by around 200 days of age, with a median survival similar to that of mutant mice homozygous for the wild-type Prmt1 allele

neoplasm

increased osteosarcoma incidence ( J:245660 )

• microPET/CT imaging suggested an increase in the presence of osteosarcomas at 100 days of age

skeleton

increased osteosarcoma incidence ( J:245660 )

• microPET/CT imaging suggested an increase in the presence of osteosarcomas at 100 days of age