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Phenotypes Associated with This Genotype
Genotype
MGI:7485833
Allelic
Composition		 Runx3tm1Itan/Runx3+
Trp53tm1Brn/Trp53tm1Brn
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm1Itan mutation (1 available); any Runx3 mutation (28 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (7 available)
Trp53tm1Brn mutation (21 available); any Trp53 mutation (249 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased osteosarcoma incidence ( J:319454 )
• decreased incidence compared to mutant mice wild-type for Runx3

mortality/aging
increased tumor-free survival time ( J:319454 )
• increased lifespan compared to mutant mice wild-type for Runx3

skeleton
decreased osteosarcoma incidence ( J:319454 )
• decreased incidence compared to mutant mice wild-type for Runx3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory