Phenotypes for Atrx Rb1 Tg(Sp7-tTA,tetO-EGFP/cre)1Amc Trp53 MGI:7482547 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Atrx^tm1Rjg/Atrx^tm1Rjg Rb1^tm3Tyj/Rb1^tm3Tyj Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrx^tm1Rjg mutation (0 available); any Atrx mutation (78 available)
Rb1^tm3Tyj mutation (12 available); any Rb1 mutation (117 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (7 available)
Trp53^tm1Brn mutation (21 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased osteosarcoma incidence ( J:329449 )

• tumor formation occurs at an earlier age compared to mutant mice wild-type for Atrx

decreased tumor latency ( J:329449 )

• increase in the rate of osteosarcoma initiation compared to mutant mice wild-type for Atrx

skeleton

increased osteosarcoma incidence ( J:329449 )

• tumor formation occurs at an earlier age compared to mutant mice wild-type for Atrx

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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