Phenotypes Associated with This Genotype

Genotype
MGI:7464191

• Allelic Composition: H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺; Memo1^{tm1c(EUCOMM)Wtsi}/Memo1^{tm1c(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * CBA/J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:233609 )

craniofacial

abnormal craniofacial bone morphology ( J:233609 )

wide coronal suture ( J:233609 )

wide metopic suture ( J:233609 )

small basisphenoid bone ( J:233609 )

• mild rostral truncation

presphenoid bone hypoplasia ( J:233609 )

• severely hypoplastic or fails to ossify

• this bone is most severely affected in the single mouse with a visible cleft palate

maxillary shelf hypoplasia ( J:233609 )

• not as severely affected as the palatine bone

premaxilla hypoplasia ( J:233609 )

palatine bone horizontal plate hypoplasia ( J:233609 )

domed cranium ( J:233609 )

cleft palate ( J:233609 )

• unlike in mice homozygous for Memo1^m1Will only a single pup ot of 10 showed a cleft palate

abnormal nasal bridge morphology ( J:233609 )

• slightly dipped

behavior/neurological

absent gastric milk in neonates ( J:233609 )

• despite absence of cleft palate in most pups

digestive/alimentary system

maxillary shelf hypoplasia ( J:233609 )

• not as severely affected as the palatine bone

palatine bone horizontal plate hypoplasia ( J:233609 )

cleft palate ( J:233609 )

• unlike in mice homozygous for Memo1^m1Will only a single pup ot of 10 showed a cleft palate

skeleton

abnormal craniofacial bone morphology ( J:233609 )

wide coronal suture ( J:233609 )

wide metopic suture ( J:233609 )

small basisphenoid bone ( J:233609 )

• mild rostral truncation

presphenoid bone hypoplasia ( J:233609 )

• severely hypoplastic or fails to ossify

• this bone is most severely affected in the single mouse with a visible cleft palate

maxillary shelf hypoplasia ( J:233609 )

• not as severely affected as the palatine bone

premaxilla hypoplasia ( J:233609 )

palatine bone horizontal plate hypoplasia ( J:233609 )

domed cranium ( J:233609 )

abnormal endochondral bone ossification ( J:233609 )

• hyoid fails to ossify

growth/size/body

presphenoid bone hypoplasia ( J:233609 )

• severely hypoplastic or fails to ossify

• this bone is most severely affected in the single mouse with a visible cleft palate

maxillary shelf hypoplasia ( J:233609 )

• not as severely affected as the palatine bone

premaxilla hypoplasia ( J:233609 )

palatine bone horizontal plate hypoplasia ( J:233609 )

cleft palate ( J:233609 )

• unlike in mice homozygous for Memo1^m1Will only a single pup ot of 10 showed a cleft palate

abnormal nasal bridge morphology ( J:233609 )

• slightly dipped

respiratory system

abnormal nasal bridge morphology ( J:233609 )

• slightly dipped