Phenotypes for Hadh MGI:7444811 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hadh^em1Jgao/Hadh^em1Jgao
Genetic Background	Not Specified

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hadh^em1Jgao mutation (0 available); any Hadh mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

oligozoospermia ( J:333351 )

teratozoospermia ( J:333351 )

coiled sperm flagellum ( J:333351 )

hairpin sperm flagellum ( J:333351 )

abnormal acrosome morphology ( J:333351 )

• deformed, mislocalized, and missing acrosome

• however, treatment with etanercept improves acrosome development

absent sperm head ( J:333351 )

multinucleated giant male germ cells ( J:333351 )

abnormal male meiosis ( J:333351 )

• partially arrested producing multinucleated giant cells

• however, treatment with etanercept improves male meiosis

increased male germ cell apoptosis ( J:333351 )

• however, treatment with etanercept improves represses germ cell apoptosis

decreased sperm progressive motility ( J:333351 )

abnormal seminiferous tubule morphology ( J:333351 )

• large vacuoles and disorganized structure

small testis ( J:333351 )

decreased testis weight ( J:333351 )

• however, treatment with etanercept improves testes weight

reduced male fertility ( J:333351 )

• male mice produced reduced litters compared with wild-type mice

• however, treatment with etanercept improves reproductive ability

premature acrosome reaction ( J:333351 )

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:333351 )

• large vacuoles and disorganized structure

small testis ( J:333351 )

decreased testis weight ( J:333351 )

• however, treatment with etanercept improves testes weight

cellular

oligozoospermia ( J:333351 )

teratozoospermia ( J:333351 )

coiled sperm flagellum ( J:333351 )

hairpin sperm flagellum ( J:333351 )

abnormal acrosome morphology ( J:333351 )

• deformed, mislocalized, and missing acrosome

• however, treatment with etanercept improves acrosome development

absent sperm head ( J:333351 )

multinucleated giant male germ cells ( J:333351 )

abnormal male meiosis ( J:333351 )

• partially arrested producing multinucleated giant cells

• however, treatment with etanercept improves male meiosis

increased male germ cell apoptosis ( J:333351 )

• however, treatment with etanercept improves represses germ cell apoptosis

decreased sperm progressive motility ( J:333351 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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