Analysis Tools
cellular
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• significantly reduced of germ cells in mutant female adult ovaries
|
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• reduction of germ cells was observed in mutant testes at 14 weeks with almost no spermatogenic cells being detected
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azoospermia
(
J:326549
)
|
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• lack of spermatazoa in caput and caudal epididymis
|
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• impaired function of the centrosome linker
• significant increase in centrosome separation in tissue samples from 1 to 3 micrometers
• the average inter-centrosomal distance was increased from 0.5 micrometers in control mouse embryonic fibroblasts (MEFs) to 5 micrometers in
mutant MEFs
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endocrine/exocrine glands
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• > 20% reduction in ovary weight
|
|
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• fewer seminiferous tubules are present
• decrease celluarity of tubules
• loss of normal organization of spermatogenic cells
|
small testis
(
J:326549
)
|
|
• 80% reduction in testis size
|
reproductive system
|
|
• significantly reduced of germ cells in mutant female adult ovaries
|
|
|
• reduction of germ cells was observed in mutant testes at 14 weeks with almost no spermatogenic cells being detected
|
azoospermia
(
J:326549
)
|
|
• lack of spermatazoa in caput and caudal epididymis
|
|
|
• > 20% reduction in ovary weight
|
|
|
• fewer seminiferous tubules are present
• decrease celluarity of tubules
• loss of normal organization of spermatogenic cells
|
small testis
(
J:326549
)
|
|
• 80% reduction in testis size
|
|
|
• 50% reduction in litter size, suggesting hypo-fertility
|
