Phenotypes Associated with This Genotype

Genotype
MGI:7444211

• Allelic Composition: Rr272^em1Issa/Rr272^em1Issa
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:333875 )

N • normal eye size in E14.5 embryos and P22 mice

abnormal Muller cell morphology ( J:333875 )

• increased number of Mueller glia in adult retinas

increased retina cone cell number ( J:333875 )

• in adult retinas

increased retina rod cell number ( J:333875 )

• in adult retinas

absent retina bipolar cells ( J:333875 )

thin retina inner nuclear layer ( J:333875 )

thin retina inner plexiform layer ( J:333875 )

thick retina outer nuclear layer ( J:333875 )

decreased total retina thickness ( J:333875 )

• 20% thinner in adult mice

abnormal electroretinogram waveform feature ( J:333875 )

• absent b-wave

• normal a-wave

absent b-wave ( J:333875 )

binocular blindness ( J:333875 )

nervous system

abnormal Muller cell morphology ( J:333875 )

• increased number of Mueller glia in adult retinas

increased retina cone cell number ( J:333875 )

• in adult retinas

increased retina rod cell number ( J:333875 )

• in adult retinas

absent retina bipolar cells ( J:333875 )

cellular

cellular phenotype ( J:333875 )

N • normal retinal cell proliferation in E14.5 embryos and P0, P4, P7 and P10 mice

abnormal Muller cell morphology ( J:333875 )

• increased number of Mueller glia in adult retinas