Rr272em1Issa
Endonuclease-mediated Allele Detail
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Symbol: |
Rr272em1Issa |
Name: |
regulatory region 272; endonuclease-mediated mutation 1, Issam Aldiri |
MGI ID: |
MGI:7443202 |
Synonyms: |
VSX2-SE-KO |
Gene: |
Rr272 Location: unknown Genetic Position: Chr12, Syntenic
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Alliance: |
Rr272em1Issa page
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Allele Type: |
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Endonuclease-mediated (Modified regulatory region) |
Mutations: |
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Intergenic deletion, Intragenic deletion
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Rr272em1Issa involves 6 genes/genome features (Rr274, Rr275, Rr276 ...)
View all
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Mutation details: The Vsx2 super-enhancer was targeted with sgRNAs (targeting GCAGGCCATGTGCTCGTCGA and CAGGGTGCAGGCTGACAACG) using CRISPR/Cas9 technology, resulting in the deletion of super-enhancer component enhancers Rr274, Rr275 and Rr276 (which contains Rr261800 and Rr268660), but not Rr273, and an alternative exon 1 of Lin52. The deletion is 31721 bp (chr12:84579817-84611537 (GRCm39)).
(J:333875)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rr272 Mutation: |
0 strains or lines available
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Original: |
J:333875 Bian F, et al., Functional analysis of the Vsx2 super-enhancer uncovers distinct cis-regulatory circuits controlling Vsx2 expression during retinogenesis. Development. 2022 Aug 1;149(15):dev200642 |
All: |
1 reference(s) |
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