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Phenotypes Associated with This Genotype
Genotype
MGI:7439999
Allelic
Composition		 Tet1tm1.2Jae/Tet1tm1.2Jae
Tet2tm1.1Iaai/Tet2+
Tet3tm1.1Yzhg/Tet3tm1.1Yzhg
Tg(Rorc-cre)1Litt/0
Genetic
Background		 involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1tm1.2Jae mutation (0 available); any Tet1 mutation (147 available)
Tet2tm1.1Iaai mutation (3 available); any Tet2 mutation (783 available)
Tet3tm1.1Yzhg mutation (0 available); any Tet3 mutation (60 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased effector memory T-helper cell number ( J:333574 )
• greatly reduced CD4 expression upon T cell proliferation

immune system
immune system phenotype ( J:333574 )
N
• no autoimmune phenotypes
• normal spleen and lymph node size
• normal proportions of naive CD44- CD62L+ T lymphocyte compartments
decreased effector memory T-helper cell number ( J:333574 )
• greatly reduced CD4 expression upon T cell proliferation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory