Phenotypes Associated with This Genotype

Genotype
MGI:7439373

• Allelic Composition: Guf1^tm1.1Nju/Guf1^tm1.1Nju
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm mitochondrial sheath morphology ( J:333298 )

♂ • fractured or torn away sheath with aberrant mitochondria that lack the inner-membrane system

oligozoospermia ( J:333298 )

♂ • very few elongated spermatids in seminiferous tubules

increased male germ cell apoptosis ( J:333298 )

♂

asthenozoospermia ( J:333298 )

♂

small seminiferous tubules ( J:333298 )

♂

decreased testis weight ( J:333298 )

♂

abnormal spermiogenesis ( J:333298 )

♂ • round spermatid development arrests at steps 5 to 8

male infertility ( J:333298 )

♂

homeostasis/metabolism

increased circulating testosterone level ( J:333298 )

♂

decreased follicle stimulating hormone level ( J:333298 )

♂

decreased luteinizing hormone level ( J:333298 )

♂

cellular

abnormal sperm mitochondrial sheath morphology ( J:333298 )

♂ • fractured or torn away sheath with aberrant mitochondria that lack the inner-membrane system

oligozoospermia ( J:333298 )

♂ • very few elongated spermatids in seminiferous tubules

increased male germ cell apoptosis ( J:333298 )

♂

asthenozoospermia ( J:333298 )

♂

endocrine/exocrine glands

small seminiferous tubules ( J:333298 )

♂

decreased testis weight ( J:333298 )

♂