Phenotypes Associated with This Genotype

Genotype
MGI:7408241

• Allelic Composition: Orc1^tm1.1Gle/Orc1^tm1.1Gle; Alb^{tm1(cre/ERT2)Mtz}/Alb⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:272584 )

N • mice fed tamoxifen chow at 6 weeks of age (postweaning) show no significant differences in hepatocyte nuclear size or ploidy levels at 9 weeks of age relative to controls

increased hepatocyte karyomegaly ( J:272584 )

• mice fed tamoxifen chow at birth (preweaning) exhibit livers with fewer hepatocytes containing visibly larger nuclei at 3 weeks of age

decreased hepatocyte number ( J:272584 )

• mice fed tamoxifen chow at birth (preweaning) exhibit livers with fewer hepatocytes at 3 weeks of age

cellular

cellular phenotype ( J:272584 )

N • mice fed tamoxifen chow at 6 weeks of age (postweaning) show no significant differences in hepatocyte ploidy levels at 9 weeks of age relative to controls

increased hepatocyte karyomegaly ( J:272584 )

• mice fed tamoxifen chow at birth (preweaning) exhibit livers with fewer hepatocytes containing visibly larger nuclei at 3 weeks of age

polyploidy ( J:272584 )

• mice fed tamoxifen chow at birth (preweaning) exhibit hepatocytes accumulating 4C or greater DNA content by 3 weeks of age