Phenotypes Associated with This Genotype

Genotype
MGI:7380640

• Allelic Composition: Dancr^em1.1Bcgen/Dancr^em1.1Bcgen
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:329926 )

• in a DEN-CCl4-induced carcinogenesis model, mice show reduced hepatocellular carcinoma development, with a 44.4% of tumor formation rate at 25 weeks compared to 100% for wild-type mice and with a lower proportion of tumors at 21 weeks of age

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:329926 )

• in a DEN-CCl4-induced carcinogenesis model, mice show reduced hepatocellular carcinoma development, with a 44.4% of tumor formation rate at 25 weeks compared to 100% for wild-type mice and with a lower proportion of tumors at 21 weeks of age

liver/biliary system

abnormal liver morphology ( J:329926 )

• in a diethylnitrosamine-carbon tetrachloride (DEN-CCl4)-induced carcinogenesis model, mice show reduced hepatic fibrosis compared to wild-type mice