Phenotypes Associated with This Genotype

Genotype
MGI:7380438

• Allelic Composition: Herc6^tm1Kshim/Herc6^tm1Kshim
• Genetic Background: either: B6.Cg-Herc6^tm1Kshim or (involves: C57BL/6NCrlj * CBA/JNCrlj)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal seminal vesicle epithelium morphology ( J:330459 )

♂ • only slight epithelial hyperplasia with cystic dilatation of seminal vesicles is seen

enlarged seminal vesicle ( J:330459 )

♂ • males begin to show abdominal distension at 28 weeks of age due to severe enlargement of seminal vesicles

♂ • however, glandular hypoplasia and benign hypertrophy of the prostate are not seen

endocrine/exocrine glands

abnormal seminal vesicle epithelium morphology ( J:330459 )

♂ • only slight epithelial hyperplasia with cystic dilatation of seminal vesicles is seen

enlarged seminal vesicle ( J:330459 )

♂ • males begin to show abdominal distension at 28 weeks of age due to severe enlargement of seminal vesicles

♂ • however, glandular hypoplasia and benign hypertrophy of the prostate are not seen

immune system

immune system phenotype ( J:330459 )

N • macrophages show normal IFN responses

N • MEFs infected with Sendai virus or stimulated with poly I:C show no differences in the production of IFN-beta and IL-6 from wild-type MEFs and MEFs show no differences in the antiviral response against vesicular stomatitis virus infection

hematopoietic system

hematopoietic system phenotype ( J:330459 )

N • peripheral blood cell counts and other blood parameters with or without lipopolysaccharide (LPS) stimulation are normal