Herc6^tm1Kshim
Targeted Allele Detail

Summary

• Symbol: Herc6^tm1Kshim
• Name: hect domain and RLD 6; targeted mutation 1, Kunitada Shimotohno
• MGI ID: MGI:7380421
• Gene: Herc6 Location: Chr6:57557985-57641617 bp, + strand Genetic Position: Chr6, 27.82 cM, cytoband C1
• Alliance: Herc6^tm1Kshim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330459
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP flanked neomycin selection cassette replaced part of exon 20 to exon 22. This record represents line 1, #29. Western blot analysis confirmed absence of protein and defective protein ISGylation. (J:330459)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Herc6 Mutation: 57 strains or lines available

References

• Original: J:330459 Arimoto K, et al., Murine Herc6 Plays a Critical Role in Protein ISGylation In Vivo and Has an ISGylation-Independent Function in Seminal Vesicles. J Interferon Cytokine Res. 2015 May;35(5):351-8
• All: 1 reference(s)