Phenotypes Associated with This Genotype

Genotype
MGI:7380333

• Allelic Composition: Has2^tm1.1Chg/Has2^tm1.1Chg; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:283393 )

• die within hours of birth due to respiratory and feeding difficulties

craniofacial

abnormal Meckel's cartilage morphology ( J:283393 )

• at E14.5, hyaluronic acid is only sporadically present

short Meckel's cartilage ( J:283393 )

• at E13.5

abnormal mandible morphology ( J:283393 )

• at E14.5, hyaluronic acid content is reduced in the mesenchymal cells

short mandible ( J:283393 )

• shorter but wider

abnormal maxilla morphology ( J:283393 )

• at E14.5, hyaluronic acid content is reduced in the mesenchymal cells

micrognathia ( J:283393 )

abnormal palate development ( J:283393 )

• at E13.5, hyaluronic acid content is reduced and not uniformly present in the palatal mesenchyme unlike in wild-type controls

• at E14.5, hyaluronic acid content is increased in the anterior palatal mesenchyme but lower in the posterior palatal mesenchyme and almost absent in the medial aspect compared to E13.5 embryos

• at E13.5 and early E14.5, palatal shelves appear similar in shape but are smaller in area compared to controls

• at E13.5, ECM space is reduced and mesenchymal cell density is increased in palatal shelves

failure of palatal shelf elevation ( J:283393 )

• remain lateral to the tongue at P0

decreased palatal shelf size ( J:283393 )

• at E13.5 and early E14.5, palatal shelves appear similar in shape but are smaller in area compared to controls

abnormal oral cavity morphology ( J:283393 )

• reduced vertical dimension of the oral-nasal cavity

complete cleft palate ( J:283393 )

• complete cleft palate

protruding tongue ( J:283393 )

• tongue occupies the entire oral-nasal cavity at P0

increased tongue size ( J:283393 )

• appears wider at early E14.5

skeleton

abnormal Meckel's cartilage morphology ( J:283393 )

• at E14.5, hyaluronic acid is only sporadically present

short Meckel's cartilage ( J:283393 )

• at E13.5

abnormal mandible morphology ( J:283393 )

• at E14.5, hyaluronic acid content is reduced in the mesenchymal cells

short mandible ( J:283393 )

• shorter but wider

abnormal maxilla morphology ( J:283393 )

• at E14.5, hyaluronic acid content is reduced in the mesenchymal cells

micrognathia ( J:283393 )

digestive/alimentary system

abnormal palate development ( J:283393 )

• at E13.5, hyaluronic acid content is reduced and not uniformly present in the palatal mesenchyme unlike in wild-type controls

• at E14.5, hyaluronic acid content is increased in the anterior palatal mesenchyme but lower in the posterior palatal mesenchyme and almost absent in the medial aspect compared to E13.5 embryos

• at E13.5 and early E14.5, palatal shelves appear similar in shape but are smaller in area compared to controls

• at E13.5, ECM space is reduced and mesenchymal cell density is increased in palatal shelves

failure of palatal shelf elevation ( J:283393 )

• remain lateral to the tongue at P0

decreased palatal shelf size ( J:283393 )

• at E13.5 and early E14.5, palatal shelves appear similar in shape but are smaller in area compared to controls

complete cleft palate ( J:283393 )

• complete cleft palate

protruding tongue ( J:283393 )

• tongue occupies the entire oral-nasal cavity at P0

increased tongue size ( J:283393 )

• appears wider at early E14.5

growth/size/body

abnormal mandible morphology ( J:283393 )

• at E14.5, hyaluronic acid content is reduced in the mesenchymal cells

short mandible ( J:283393 )

• shorter but wider

abnormal maxilla morphology ( J:283393 )

• at E14.5, hyaluronic acid content is reduced in the mesenchymal cells

micrognathia ( J:283393 )

abnormal palate development ( J:283393 )

• at E13.5, hyaluronic acid content is reduced and not uniformly present in the palatal mesenchyme unlike in wild-type controls

• at E14.5, hyaluronic acid content is increased in the anterior palatal mesenchyme but lower in the posterior palatal mesenchyme and almost absent in the medial aspect compared to E13.5 embryos

• at E13.5 and early E14.5, palatal shelves appear similar in shape but are smaller in area compared to controls

• at E13.5, ECM space is reduced and mesenchymal cell density is increased in palatal shelves

failure of palatal shelf elevation ( J:283393 )

• remain lateral to the tongue at P0

decreased palatal shelf size ( J:283393 )

• at E13.5 and early E14.5, palatal shelves appear similar in shape but are smaller in area compared to controls

abnormal oral cavity morphology ( J:283393 )

• reduced vertical dimension of the oral-nasal cavity

complete cleft palate ( J:283393 )

• complete cleft palate

protruding tongue ( J:283393 )

• tongue occupies the entire oral-nasal cavity at P0

increased tongue size ( J:283393 )

• appears wider at early E14.5