Phenotypes Associated with This Genotype

Genotype
MGI:7378350

• Allelic Composition: Lrfn2^tm1.1Jaru/Lrfn2^tm1.1Jaru
• Genetic Background: B6.129P2(Cg)-Lrfn2^tm1.1Jaru

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal erythropoiesis ( J:301285 )

• in the early and late phases

abnormal bone marrow hematopoietic cell morphology ( J:301285 )

• reduced granulocyte/macrophage colony forming units

decreased erythroid progenitor cell number ( J:301285 )

• marginally decreased

increased erythrocyte cell number ( J:301285 )

• at 6 and 12 months

decreased hematocrit ( J:301285 )

• at 6 and 12 months

increased hemoglobin content ( J:301285 )

• normocytic erythrocythemia at 6 and 12 months

decreased mean corpuscular hemoglobin ( J:301285 )

• slightly at 3 months

decreased leukocyte cell number ( J:301285 )

• at 6 months

decreased granulocyte number ( J:301285 )

• at 6 months

decreased lymphocyte cell number ( J:301285 )

• at 6 months

growth/size/body

decreased body weight ( J:301285 )

• at 10 to 12 months of age

immune system

decreased leukocyte cell number ( J:301285 )

• at 6 months

decreased granulocyte number ( J:301285 )

• at 6 months

decreased lymphocyte cell number ( J:301285 )

• at 6 months

homeostasis/metabolism

decreased circulating erythropoietin level ( J:301285 )