Phenotypes Associated with This Genotype

Genotype
MGI:7355998

• Allelic Composition: Gt(ROSA)26Sor^tm2Sho/Gt(ROSA)26Sor⁺; Sp8^tm1Smb/Sp8^tm1Smb; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

increased cranial neural crest cell apoptosis ( J:200761 )

• at E9.5, a 4-fold increase in apoptosis is detected in the neural crest cells (NCCs) of the facial mesenchyme

• at E10.5, apoptosis is significantly increased in both the medial nasal prominences (MNP) and lateral nasal prominences (LNP) and the olfactory pit

increased head mesenchyme apoptosis ( J:200761 )

• at E9.5, a 4-fold increase in apoptosis is detected in the neural crest cells (NCCs) of the facial mesenchyme

• at E10.5, apoptosis is significantly increased in both the medial nasal prominences (MNP) and lateral nasal prominences (LNP) and the olfactory pit

decreased cranial neural crest cell proliferation ( J:200761 )

• at E9.5, but not at E8.5, NCC proliferation is significantly reduced in the facial mesenchyme

• at E10.5, cell proliferation is significantly reduced in the olfactory pit and the lateral nasal prominences (LNP), but not in the medial nasal prominences (MNP)

nervous system

increased embryonic neuroepithelium apoptosis ( J:200761 )

• at E8.5, a 3-fold increase in apoptosis is detected in the anterior neuroepithelium of the cranial neural folds, including the anterior neural ridge (ANR); however, no elevated apoptosis is observed in the neural crest cells (NCCs) at this age

cellular

increased cranial neural crest cell apoptosis ( J:200761 )

• at E9.5, a 4-fold increase in apoptosis is detected in the neural crest cells (NCCs) of the facial mesenchyme

• at E10.5, apoptosis is significantly increased in both the medial nasal prominences (MNP) and lateral nasal prominences (LNP) and the olfactory pit

increased head mesenchyme apoptosis ( J:200761 )

• at E9.5, a 4-fold increase in apoptosis is detected in the neural crest cells (NCCs) of the facial mesenchyme

• at E10.5, apoptosis is significantly increased in both the medial nasal prominences (MNP) and lateral nasal prominences (LNP) and the olfactory pit

increased embryonic neuroepithelium apoptosis ( J:200761 )

• at E8.5, a 3-fold increase in apoptosis is detected in the anterior neuroepithelium of the cranial neural folds, including the anterior neural ridge (ANR); however, no elevated apoptosis is observed in the neural crest cells (NCCs) at this age

decreased cranial neural crest cell proliferation ( J:200761 )

• at E9.5, but not at E8.5, NCC proliferation is significantly reduced in the facial mesenchyme

• at E10.5, cell proliferation is significantly reduced in the olfactory pit and the lateral nasal prominences (LNP), but not in the medial nasal prominences (MNP)

craniofacial

abnormal nasal pit morphology ( J:200761 )

• at E10.5, apoptosis is significantly increased whereas cell proliferation is significantly reduced in the olfactory pit

growth/size/body

increased head mesenchyme apoptosis ( J:200761 )

• at E9.5, a 4-fold increase in apoptosis is detected in the neural crest cells (NCCs) of the facial mesenchyme

• at E10.5, apoptosis is significantly increased in both the medial nasal prominences (MNP) and lateral nasal prominences (LNP) and the olfactory pit

respiratory system

abnormal nasal pit morphology ( J:200761 )

• at E10.5, apoptosis is significantly increased whereas cell proliferation is significantly reduced in the olfactory pit