Phenotypes Associated with This Genotype

Genotype
MGI:7344037

• Allelic Composition: Men1^tm1.2Ctre/Men1^tm1.2Ctre; Tg(Pax3-cre)1Joe/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:127545 )

• pups die at birth (14 of 36) or during the first postnatal day (P1)

craniofacial

short soft palate ( J:127545 )

• some newborns show a shortened palate in relation to the epiglottis, trachea and tongue

cleft secondary palate ( J:127545 )

• 2 of 36 newborns exhibit a bilateral cleft of the secondary palate

bilateral cleft palate ( J:127545 )

skeleton

abnormal rib morphology ( J:127545 )

• rib defects involve different ribs among mutant mice and include fusions and bifurcations in the distal regions of the ribs unilaterally or bilaterally

digestive/alimentary system

short soft palate ( J:127545 )

• some newborns show a shortened palate in relation to the epiglottis, trachea and tongue

cleft secondary palate ( J:127545 )

• 2 of 36 newborns exhibit a bilateral cleft of the secondary palate

bilateral cleft palate ( J:127545 )

growth/size/body

short soft palate ( J:127545 )

• some newborns show a shortened palate in relation to the epiglottis, trachea and tongue

cleft secondary palate ( J:127545 )

• 2 of 36 newborns exhibit a bilateral cleft of the secondary palate

bilateral cleft palate ( J:127545 )