Phenotypes for Bcor Isl1 MGI:7343918 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Bcor^tm1.1Vjba/Y Isl1^tm1(cre)Sev/Isl1⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcor^tm1.1Vjba mutation (1 available); any Bcor mutation (18 available)
Isl1^tm1(cre)Sev mutation (1 available); any Isl1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal aortic arch morphology ( J:296645 )

• aortic arch abnormalities in 13% of hearts

persistent truncus arteriosus ( J:296645 )

• at E13.5 in 65% of embryos

perimembraneous ventricular septal defect ( J:296645 )

• at E13.5 and E14.5

limbs/digits/tail

syndactyly ( J:296645 )

• show simple or complex syndactyly of the second and third digits in 4 of 17 embryos at E14.5

mortality/aging

lethality throughout fetal growth and development ( J:296645 )

• begin to see decrease in numbers after E13.5

preweaning lethality, complete penetrance ( J:296645 )

• none found at weaning

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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