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Phenotypes Associated with This Genotype
Genotype
MGI:7343897
Allelic
Composition		 Bcortm1.1Vjba/Y
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S1/Sv * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcortm1.1Vjba mutation (1 available); any Bcor mutation (18 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
complete cleft palate ( J:296645 )
• all show severe clefting
• complete cleft of both the hard and soft palates

endocrine/exocrine glands
abnormal major salivary gland morphology ( J:296645 )
• supernumerary pair of major salivary glands embedded between the tongue and the floor of the mouth
• ectopic glands contain mainly serous acini but also have groups of mucous acini

mortality/aging
neonatal lethality, complete penetrance ( J:296645 )
• fail to thrive and die within a few hours of birth

digestive/alimentary system
complete cleft palate ( J:296645 )
• all show severe clefting
• complete cleft of both the hard and soft palates
abnormal major salivary gland morphology ( J:296645 )
• supernumerary pair of major salivary glands embedded between the tongue and the floor of the mouth
• ectopic glands contain mainly serous acini but also have groups of mucous acini

growth/size/body
complete cleft palate ( J:296645 )
• all show severe clefting
• complete cleft of both the hard and soft palates

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory