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Phenotypes Associated with This Genotype
Genotype
MGI:7338996
Allelic
Composition		 Ezh2tm2Sho/Ezh2+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Kdm6btm1.1Rbo/Kdm6btm1.1Rbo
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2tm2Sho mutation (1 available); any Ezh2 mutation (71 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Kdm6btm1.1Rbo mutation (1 available); any Kdm6b mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
craniofacial phenotype ( J:323190 )
N
• development of the palatine processes of the maxilla and palatine bones and proliferation and differentiation of palatal mesenchymal cells are restored by conditional deletion of one copy of Ezh2 compared to mutant mice with wild-type Ezh2
cleft palate ( J:323190 )
• conditional deletion of one copy of Ezh2 rescues cleft palate with 70% efficiency

digestive/alimentary system
cleft palate ( J:323190 )
• conditional deletion of one copy of Ezh2 rescues cleft palate with 70% efficiency

growth/size/body
cleft palate ( J:323190 )
• conditional deletion of one copy of Ezh2 rescues cleft palate with 70% efficiency

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory