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Phenotypes Associated with This Genotype
Genotype
MGI:7338918
Allelic
Composition		 Setdb1tm1.1Yshk/Setdb1tm1.1Yshk
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Setdb1tm1.1Yshk mutation (1 available); any Setdb1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:321816 )
• mice die shortly after birth due to cleft palate defect

craniofacial
abnormal tooth development ( J:321816 )
• hypoplasia of the teeth at E14.5 and E15.5
abnormal palatal mesenchymal cell proliferation ( J:321816 )
• reduced proliferation of palatal mesenchymal cells at E14.5 as determined by BrdU staining, with no significant change in palatal mesenchymal cell apoptosis
abnormal secondary palate development ( J:321816 )
• decreased mRNA expression of Bmp4, Fgf10 and Pax9 in both the anterior and posterior parts of the palatal shelf at E13.5, with reduction of Wnt5a mRNA expression in the anterior part and of Bmpr1a expression in the posterior part of the palatal shelf
• loss of phospho-SMAD1/5/9 expression in the palatal mesenchyme at E13.5
cleft secondary palate ( J:321816 )
• cleft palate with full penetrance
delayed palatal shelf elevation ( J:321816 )
• delayed palatal shelf elevation at E14.5 and E15.5
tongue hypoplasia ( J:321816 )
• at E14.5 and E15.5

growth/size/body
abnormal tooth development ( J:321816 )
• hypoplasia of the teeth at E14.5 and E15.5
abnormal palatal mesenchymal cell proliferation ( J:321816 )
• reduced proliferation of palatal mesenchymal cells at E14.5 as determined by BrdU staining, with no significant change in palatal mesenchymal cell apoptosis
abnormal secondary palate development ( J:321816 )
• decreased mRNA expression of Bmp4, Fgf10 and Pax9 in both the anterior and posterior parts of the palatal shelf at E13.5, with reduction of Wnt5a mRNA expression in the anterior part and of Bmpr1a expression in the posterior part of the palatal shelf
• loss of phospho-SMAD1/5/9 expression in the palatal mesenchyme at E13.5
cleft secondary palate ( J:321816 )
• cleft palate with full penetrance
delayed palatal shelf elevation ( J:321816 )
• delayed palatal shelf elevation at E14.5 and E15.5
tongue hypoplasia ( J:321816 )
• at E14.5 and E15.5

digestive/alimentary system
abnormal palatal mesenchymal cell proliferation ( J:321816 )
• reduced proliferation of palatal mesenchymal cells at E14.5 as determined by BrdU staining, with no significant change in palatal mesenchymal cell apoptosis
abnormal secondary palate development ( J:321816 )
• decreased mRNA expression of Bmp4, Fgf10 and Pax9 in both the anterior and posterior parts of the palatal shelf at E13.5, with reduction of Wnt5a mRNA expression in the anterior part and of Bmpr1a expression in the posterior part of the palatal shelf
• loss of phospho-SMAD1/5/9 expression in the palatal mesenchyme at E13.5
cleft secondary palate ( J:321816 )
• cleft palate with full penetrance
delayed palatal shelf elevation ( J:321816 )
• delayed palatal shelf elevation at E14.5 and E15.5
tongue hypoplasia ( J:321816 )
• at E14.5 and E15.5

skeleton
abnormal tooth development ( J:321816 )
• hypoplasia of the teeth at E14.5 and E15.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/29/2025
MGI 6.24 		The Jackson Laboratory