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Phenotypes Associated with This Genotype
Genotype
MGI:7338918
Allelic
Composition
Setdb1tm1.1Yshk/Setdb1tm1.1Yshk
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Setdb1tm1.1Yshk mutation (1 available); any Setdb1 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die shortly after birth due to cleft palate defect

craniofacial
• hypoplasia of the teeth at E14.5 and E15.5
• reduced proliferation of palatal mesenchymal cells at E14.5 as determined by BrdU staining, with no significant change in palatal mesenchymal cell apoptosis
• decreased mRNA expression of Bmp4, Fgf10 and Pax9 in both the anterior and posterior parts of the palatal shelf at E13.5, with reduction of Wnt5a mRNA expression in the anterior part and of Bmpr1a expression in the posterior part of the palatal shelf
• loss of phospho-SMAD1/5/9 expression in the palatal mesenchyme at E13.5
• cleft palate with full penetrance
• delayed palatal shelf elevation at E14.5 and E15.5
• at E14.5 and E15.5

growth/size/body
• hypoplasia of the teeth at E14.5 and E15.5
• reduced proliferation of palatal mesenchymal cells at E14.5 as determined by BrdU staining, with no significant change in palatal mesenchymal cell apoptosis
• decreased mRNA expression of Bmp4, Fgf10 and Pax9 in both the anterior and posterior parts of the palatal shelf at E13.5, with reduction of Wnt5a mRNA expression in the anterior part and of Bmpr1a expression in the posterior part of the palatal shelf
• loss of phospho-SMAD1/5/9 expression in the palatal mesenchyme at E13.5
• cleft palate with full penetrance
• delayed palatal shelf elevation at E14.5 and E15.5
• at E14.5 and E15.5

digestive/alimentary system
• reduced proliferation of palatal mesenchymal cells at E14.5 as determined by BrdU staining, with no significant change in palatal mesenchymal cell apoptosis
• decreased mRNA expression of Bmp4, Fgf10 and Pax9 in both the anterior and posterior parts of the palatal shelf at E13.5, with reduction of Wnt5a mRNA expression in the anterior part and of Bmpr1a expression in the posterior part of the palatal shelf
• loss of phospho-SMAD1/5/9 expression in the palatal mesenchyme at E13.5
• cleft palate with full penetrance
• delayed palatal shelf elevation at E14.5 and E15.5
• at E14.5 and E15.5

skeleton
• hypoplasia of the teeth at E14.5 and E15.5


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/29/2025
MGI 6.24
The Jackson Laboratory