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Phenotypes Associated with This Genotype
Genotype
MGI:7335081
Allelic
Composition		 Gt(ROSA)26Sortm3(CAG-Shox2)Fawa/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Meis2tm1.1Zkoz/Meis2tm1.1Zkoz
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(CAG-Shox2)Fawa mutation (0 available); any Gt(ROSA)26Sor mutation (1098 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Meis2tm1.1Zkoz mutation (0 available); any Meis2 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
absent palate bones ( J:286823 )
• complete absence of palatal bones in all mice
cleft secondary palate ( J:286823 )
• complete cleft is seen in 9 of 14
submucous cleft palate ( J:286823 )
• in 5 of 14
• manifests as fused anterior palate and cleft soft palate

skeleton
absent palate bones ( J:286823 )
• complete absence of palatal bones in all mice

digestive/alimentary system
absent palate bones ( J:286823 )
• complete absence of palatal bones in all mice
cleft secondary palate ( J:286823 )
• complete cleft is seen in 9 of 14
submucous cleft palate ( J:286823 )
• in 5 of 14
• manifests as fused anterior palate and cleft soft palate

growth/size/body
absent palate bones ( J:286823 )
• complete absence of palatal bones in all mice
cleft secondary palate ( J:286823 )
• complete cleft is seen in 9 of 14
submucous cleft palate ( J:286823 )
• in 5 of 14
• manifests as fused anterior palate and cleft soft palate

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory