Phenotypes Associated with This Genotype

Genotype
MGI:7335064

• Allelic Composition: H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺; Meis2^tm1.1Zkoz/Meis2^tm1.1Zkoz
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal palate morphology ( J:286823 )

• palatal shelves are reduced in size in the posterior region where the soft palate forms

absent maxillary shelf ( J:286823 )

absent palatine bone horizontal plate ( J:286823 )

absent palate bones ( J:286823 )

• complete absence of palatal bones in all mice

abnormal palatal mesenchymal cell proliferation ( J:286823 )

• reduced proliferation of the posterior palatal mesenchyme but not of the anterior mesenchyme

abnormal palatal rugae morphology ( J:286823 )

• disorganized in mice with submucous cleft

cleft secondary palate ( J:286823 )

• complete cleft is seen in 81 of 170 mice with submucous cleft seen in the rest (89 of 170)

abnormal palatal shelf elevation ( J:286823 )

• in some mice the anterior palatal shelves are deformed and fail to elevate

cleft soft palate ( J:286823 )

submucous cleft palate ( J:286823 )

• failure of bone formation in the hard palate domain

abnormal tongue muscle morphology ( J:286823 )

• disorganized fibers

decreased tongue size ( J:286823 )

• smaller with disorganized muscle fibers

muscle

abnormal tongue muscle morphology ( J:286823 )

• disorganized fibers

skeleton

absent maxillary shelf ( J:286823 )

absent palatine bone horizontal plate ( J:286823 )

absent palate bones ( J:286823 )

• complete absence of palatal bones in all mice

abnormal intramembranous bone ossification ( J:286823 )

• in mice with submucous cleft palate, anterior shelves elevate and fuse but expression analysis indicates that osteogenesis fails to initiate

• however, osteogenesis does occur in the parts of the maxillary bone at either end of the nasal passage

digestive/alimentary system

abnormal palate morphology ( J:286823 )

• palatal shelves are reduced in size in the posterior region where the soft palate forms

absent maxillary shelf ( J:286823 )

absent palatine bone horizontal plate ( J:286823 )

absent palate bones ( J:286823 )

• complete absence of palatal bones in all mice

abnormal palatal mesenchymal cell proliferation ( J:286823 )

• reduced proliferation of the posterior palatal mesenchyme but not of the anterior mesenchyme

abnormal palatal rugae morphology ( J:286823 )

• disorganized in mice with submucous cleft

cleft secondary palate ( J:286823 )

• complete cleft is seen in 81 of 170 mice with submucous cleft seen in the rest (89 of 170)

abnormal palatal shelf elevation ( J:286823 )

• in some mice the anterior palatal shelves are deformed and fail to elevate

cleft soft palate ( J:286823 )

submucous cleft palate ( J:286823 )

• failure of bone formation in the hard palate domain

abnormal tongue muscle morphology ( J:286823 )

• disorganized fibers

decreased tongue size ( J:286823 )

• smaller with disorganized muscle fibers

growth/size/body

abnormal palate morphology ( J:286823 )

• palatal shelves are reduced in size in the posterior region where the soft palate forms

absent maxillary shelf ( J:286823 )

absent palatine bone horizontal plate ( J:286823 )

absent palate bones ( J:286823 )

• complete absence of palatal bones in all mice

abnormal palatal mesenchymal cell proliferation ( J:286823 )

• reduced proliferation of the posterior palatal mesenchyme but not of the anterior mesenchyme

abnormal palatal rugae morphology ( J:286823 )

• disorganized in mice with submucous cleft

cleft secondary palate ( J:286823 )

• complete cleft is seen in 81 of 170 mice with submucous cleft seen in the rest (89 of 170)

abnormal palatal shelf elevation ( J:286823 )

• in some mice the anterior palatal shelves are deformed and fail to elevate

cleft soft palate ( J:286823 )

submucous cleft palate ( J:286823 )

• failure of bone formation in the hard palate domain

abnormal tongue muscle morphology ( J:286823 )

• disorganized fibers

decreased tongue size ( J:286823 )

• smaller with disorganized muscle fibers