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Phenotypes Associated with This Genotype
Genotype
MGI:7316557
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Nck1tm1Paw/Nck1tm1Paw
Nck2tm3Paw/Nck2tm3Paw
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (145 available)
Nck1tm1Paw mutation (2 available); any Nck1 mutation (40 available)
Nck2tm3Paw mutation (0 available); any Nck2 mutation (29 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Assessment of atherosclerosis initiation and progression in tamoxifen-treated, high-fat diet fed Apoetm1Unc/Apoetm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1tm1Paw/Nck1tm1Paw Nck2tm3Paw/Nck2tm3Paw mice.

cardiovascular system
decreased susceptibility to diet-induced aortic fatty streak lesions ( J:326659 )
• however, serum lipoprotein levels are normal
• severity of lesions, atherosclerosis progression, and macrophage recruitment are reduced in male, but not female, following 16 weeks of a high-fat diet in tamoxifen-treated mice

immune system
decreased inflammatory response ( J:326659 )
• severity of lesions, atherosclerosis progression, and macrophage recruitment are reduced in male, but not female, following 16 weeks of a high-fat diet in tamoxifen-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory