Phenotypes Associated with This Genotype

Genotype
MGI:7294564

• Allelic Composition: Isl1^tm1(cre)Sev/Isl1⁺; Msx1^tm1Rilm/Msx1⁺; Pax9^tm1Rbal/Pax9^tm1.1Hpt
• Genetic Background: involves: 129 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:311535 )

skeleton

abnormal hyoid bone morphology ( J:311535 )

• ossification center is shorter

• angle between the greater and lesser horns is reduced

abnormal hyoid bone greater horn morphology ( J:311535 )

• reduced in length

abnormal hyoid bone lesser horn morphology ( J:311535 )

• extends laterally

abnormal inferior horn of thyroid cartilage morphology ( J:311535 )

• significantly shorter

abnormal superior horn of thyroid cartilage morphology ( J:311535 )

• reduced to a stump

craniofacial

craniofacial phenotype ( J:311535 )

• unlike in germline null mice, cleft palate is not seen

abnormal hyoid bone morphology ( J:311535 )

• ossification center is shorter

• angle between the greater and lesser horns is reduced

abnormal hyoid bone greater horn morphology ( J:311535 )

• reduced in length

abnormal hyoid bone lesser horn morphology ( J:311535 )

• extends laterally

limbs/digits/tail

preaxial polydactyly ( J:311535 )

cardiovascular system

aberrant origin of the right subclavian artery ( J:311535 )

• cervical origin in 2 of 8 neonates

respiratory system

abnormal inferior horn of thyroid cartilage morphology ( J:311535 )

• significantly shorter

abnormal superior horn of thyroid cartilage morphology ( J:311535 )

• reduced to a stump

growth/size/body

abnormal hyoid bone morphology ( J:311535 )

• ossification center is shorter

• angle between the greater and lesser horns is reduced

abnormal hyoid bone greater horn morphology ( J:311535 )

• reduced in length

abnormal hyoid bone lesser horn morphology ( J:311535 )

• extends laterally