Phenotypes Associated with This Genotype

Genotype
MGI:7294563

• Allelic Composition: Isl1^tm1(cre)Sev/Isl1⁺; Pax9^tm1Rbal/Pax9^tm1.1Hpt
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

aberrant origin of the right subclavian artery ( J:311535 )

interrupted aortic arch ( J:311535 )

abnormal common carotid artery morphology ( J:311535 )

• absent common carotid arteries in 9 of 9 mice

double outlet right ventricle ( J:311535 )

• in 5 of 9 mice

ventricular septal defect ( J:311535 )

• in 1 of 9 mice

craniofacial

craniofacial phenotype ( J:311535 )

N • unlike in germline null mice, cleft palate is not seen

endocrine/exocrine glands

thymus hypoplasia ( J:311535 )

• hypoplastic and absent from the normal position

ectopic thymus ( J:311535 )

• hypoplastic and absent from the normal position

hematopoietic system

thymus hypoplasia ( J:311535 )

• hypoplastic and absent from the normal position

ectopic thymus ( J:311535 )

• hypoplastic and absent from the normal position

immune system

thymus hypoplasia ( J:311535 )

• hypoplastic and absent from the normal position

ectopic thymus ( J:311535 )

• hypoplastic and absent from the normal position

limbs/digits/tail

preaxial polydactyly ( J:311535 )