Phenotypes Associated with This Genotype

Genotype
MGI:7284994

• Allelic Composition: Rnaseh2b^em1Anu/Rnaseh2b⁺; Tlr7^em2Anu/Tlr7⁺
• Genetic Background: C57BL/6NCrl-Rnaseh2b^em1Anu Tlr7^em2Anu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune system morphology ( J:324448 )

♀ • mice show a similar phenotype seen in female heterozygous Tlr7^em2Anu mice with no exacerbation of the cellular or serological phenotypes seen in these mice except for a mild enhancement in the expression of type I IFN signature genes

increased plasma cell number ( J:324448 )

♀ • spleen shows an increase in plasma cells

increased CD4-positive, alpha-beta T cell number ( J:324448 )

♀ • CXCR3+ extrafollicular helper CD4+ T cells are increased

increased T follicular helper cell number ( J:324448 )

♀

abnormal mature B cell morphology ( J:324448 )

♀ • spleen shows an increase in age-associated B cells (B220+CD21-CXCR5-CD19hiCD11c+)

♀ • age-associated B cells are also expanded in the blood and kidneys

increased germinal center B cell number ( J:324448 )

♀ • increase in germinal center B cells (CD19+CD95+BCL6+)

increased autoantibody level ( J:324448 )

♀ • mice develop autoantibodies to the TLR7 ligands ssRNA and Smith protein ribonucleoprotein (RNP) and DNA

hematopoietic system

increased plasma cell number ( J:324448 )

♀ • spleen shows an increase in plasma cells

increased CD4-positive, alpha-beta T cell number ( J:324448 )

♀ • CXCR3+ extrafollicular helper CD4+ T cells are increased

increased T follicular helper cell number ( J:324448 )

♀

abnormal mature B cell morphology ( J:324448 )

♀ • spleen shows an increase in age-associated B cells (B220+CD21-CXCR5-CD19hiCD11c+)

♀ • age-associated B cells are also expanded in the blood and kidneys

increased germinal center B cell number ( J:324448 )

♀ • increase in germinal center B cells (CD19+CD95+BCL6+)