Phenotypes Associated with This Genotype

Genotype
MGI:7280786

• Allelic Composition: Phf6^em1Wencc/Y; Tg(Vav1-cre)#Cgp/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased hematopoietic stem cell proliferation ( J:278804 )

♂ • reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

endocrine/exocrine glands

abnormal thymus cell ratio ( J:278804 )

♂ • reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

growth/size/body

enlarged spleen ( J:278804 )

♂ • at age 18 months

♂ • normal spleen weight and histology at age 8-12 weeks

hematopoietic system

hematopoietic system phenotype ( J:278804 )

♂N • normal white blood cell count (WBC) at age 8 weeks

increased hematopoietic stem cell proliferation ( J:278804 )

♂ • reduced number of type 2 and 3 multi-potent progenitor cells (MMP2s, MPP3s), LSK and long-term hematopoietic stem cells (LT-HSCs) in G0 cell cycle phase in bone marrow at age 8-12 weeks

abnormal thymus cell ratio ( J:278804 )

♂ • reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

enlarged spleen ( J:278804 )

♂ • at age 18 months

♂ • normal spleen weight and histology at age 8-12 weeks

increased pro-B cell number ( J:278804 )

♂ • in bone marrow at age 8-12 weeks

extramedullary hematopoiesis ( J:278804 )

♂ • in spleen red pulp at age 18 months

decreased bone marrow cell number ( J:278804 )

♂ • reduced number of LK and Lin- cells at age 8-12 weeks

increased bone marrow cell number ( J:278804 )

♂ • increased number of type 2 multi-potent progenitor cells (MPP2s) at age 8-12 weeks

decreased granulocyte monocyte progenitor cell number ( J:278804 )

♂ • in bone marrow at age 8-12 weeks

abnormal megakaryocyte morphology ( J:278804 )

♂ • hyper- and dysplastic, smaller and with hypolobulated nuclei in bone marrow at age 18 months

increased megakaryocyte cell number ( J:278804 )

♂ • hyperplastic in bone marrow at age 18 months

thrombocytopenia ( J:278804 )

♂ • in blood at age 18 months

increased B cell number ( J:278804 )

♂ • more B220+ cells at ages 8-12 weeks and 18 months

♂ • normal percentage of B cells in spleen at age 8-12 weeks

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:278804 )

♂ • increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks

abnormal effector T cell number ( J:278804 )

♂ • reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks

decreased lymphocyte cell number ( J:278804 )

♂ • in blood at age 18 months

decreased double-negative T cell number ( J:278804 )

♂ • reduced in thymus at age 8-12 weeks

decreased CD4-positive, alpha-beta T cell number ( J:278804 )

♂ • at age 8-12 weeks and in spleen at age 18 months

♂ • normal percentage in spleen at age 8-12 weeks

decreased CD8-positive, alpha-beta T cell number ( J:278804 )

♂ • at age 8-12 weeks and in spleen at age 18 months

♂ • reduced percentage in spleen at age 8-12 weeks

decreased hematopoietic stem cell number ( J:278804 )

♂ • reduced number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 18 months

increased hematopoietic stem cell number ( J:278804 )

♂ • in bone marrow at age 8-12 weeks

abnormal splenic cell ratio ( J:278804 )

♂ • reduced percentage of T cells at age 8-12 weeks

♂ • reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months

♂ • increased percentage of CD4+ T cells at age 18 months

♂ • increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months

♂ • reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months

♂ • normal percentage of CD4+ T cells at age 8-12 weeks

♂ • normal percentage of B cells at age 8-12 weeks

immune system

immune system phenotype ( J:278804 )

♂N • normal spleen and thymus weight and histology at age 8-12 weeks

♂N • normal percentage of B cells in spleen at age 8-12 weeks

♂N • normal total, naive regulatory and effector T cell function in cytokine stimulation assays at age 8-12 weeks

♂N • normal number of B cells in bone marrow other than pro-B cells at age 8-12 weeks

♂N • normal number of long-term hematopoietic stem cells (LT-HSCs) in bone marrow at age 8-12 weeks

abnormal thymus cell ratio ( J:278804 )

♂ • reduced CD4- CD8- double-negative T cell numbers at age 8-12 weeks

enlarged spleen ( J:278804 )

♂ • at age 18 months

♂ • normal spleen weight and histology at age 8-12 weeks

increased pro-B cell number ( J:278804 )

♂ • in bone marrow at age 8-12 weeks

increased B cell number ( J:278804 )

♂ • more B220+ cells at ages 8-12 weeks and 18 months

♂ • normal percentage of B cells in spleen at age 8-12 weeks

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:278804 )

♂ • increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells in spleen at age 8-12 weeks

abnormal effector T cell number ( J:278804 )

♂ • reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen at age 8-12 weeks

decreased lymphocyte cell number ( J:278804 )

♂ • in blood at age 18 months

decreased double-negative T cell number ( J:278804 )

♂ • reduced in thymus at age 8-12 weeks

decreased CD4-positive, alpha-beta T cell number ( J:278804 )

♂ • at age 8-12 weeks and in spleen at age 18 months

♂ • normal percentage in spleen at age 8-12 weeks

decreased CD8-positive, alpha-beta T cell number ( J:278804 )

♂ • at age 8-12 weeks and in spleen at age 18 months

♂ • reduced percentage in spleen at age 8-12 weeks

abnormal splenic cell ratio ( J:278804 )

♂ • reduced percentage of T cells at age 8-12 weeks

♂ • reduced percentage of CD8+ T cells at ages 8-12 weeks and 18 months

♂ • increased percentage of CD4+ T cells at age 18 months

♂ • increased percentage of naive regulatory (B220- TCRB+ CD4+ CD8- CD25+) T cells at ages 8-12 weeks and 18 months

♂ • reduced percentage of effector (B220- TCRB+ CD4+ CD8- CD25-) T cells in spleen ages 8-12 weeks and 18 months

♂ • normal percentage of CD4+ T cells at age 8-12 weeks

♂ • normal percentage of B cells at age 8-12 weeks

skeleton

skeleton phenotype ( J:278804 )

♂N • normal bone marrow cellularity and architecture at ages 8-12 weeks and 18 months