Phenotypes Associated with This Genotype

Genotype
MGI:7277821

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-MYCN,-luc)Jhsc}/Gt(ROSA)26Sor⁺; Pten^tm2.1Ppp/Pten^tm2.1Ppp; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:307910 )

♂ • median survival time of 26 weeks

♂ • castrated mice have a median survival time of 44 weeks

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:307910 )

♂ • mice develop prostate tumors that have primarily high-grade prostatic intraepithelial neoplasia at earlier time points

♂ • tumors regress post-castration but resume growth 24 weeks post-castration

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:307910 )

♂ • mice develop prostate tumors that have primarily high-grade prostatic intraepithelial neoplasia at earlier time points

♂ • tumors regress post-castration but resume growth 24 weeks post-castration

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:307910 )

♂ • mice develop prostate tumors that have primarily high-grade prostatic intraepithelial neoplasia at earlier time points

♂ • tumors regress post-castration but resume growth 24 weeks post-castration